Rimantadine Hydrochloride CAS No. 1501-84-4
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introduce
Rimantadine Hydrochloride is an adamantane-derived antiviral API that inhibits influenza A virus replication by blocking the viral M2 ion channel. It is used for the prophylaxis and treatment of influenza A virus infections with favorable tolerability.
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Physical and chemical properties
Rimantadine Hydrochloride possesses key physical and chemical characteristics as follows:
- Melting Point: >300 °C
- Solubility: Freely soluble in water; slightly soluble in chloroform, DMSO, methanol
- Storage Conditions: Inert atmosphere, room temperature
Specific Antiviral Activity: Potently inhibits multiple subtypes of influenza A virus (H1N1, H2N2, H3N2) by blocking viral uncoating and replication.
Favorable Tolerability: Lower incidence of central nervous system side effects compared with amantadine.
Good Physicochemical Properties: High water solubility supports formulation development; stable under recommended storage.
Oral Bioavailability: Well-absorbed orally with good pharmacokinetic properties for oral dosage forms.
Dual Prophylactic and Therapeutic Use: Effective for both prevention and early treatment of influenza A.
Used as a core antiviral raw material for oral anti-influenza formulations.
Suitable for the preparation of products for prophylaxis of influenza A infection in adults and children.
Applied in the development of medications for early intervention and treatment of influenza A in adults.
Rimantadine Hydrochloride is a well-established anti-influenza A API with a clear mechanism, reliable quality and favorable safety profile. It is a preferred raw material for antiviral drug development, widely used in the prevention and treatment of influenza A infections.
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