0102030405
Pemetrexed acid CAS No.137281-23-3 Pharmaceutical Intermediates
02
introduce
Pemetrexed acid is a potent antifolate chemotherapy drug that plays a vital role in the treatment of malignant pleural mesothelioma and non-small cell lung cancer (NSCLC). As a multi-target inhibitor of folate-dependent enzymes, pemetrexed acid can disrupt the synthesis of nucleic acids and proteins, thereby inhibiting the growth of tumor cells. Our company specializes in the production, research and trade of pemetrexed acid, ensuring that we meet the diverse needs of our customers in the pharmaceutical industry.
02
Physical and chemical properties
Pemetrexed acid is characterized by its white to off-white crystalline powder. Its molecular weight is approximately 427.41 g/mol. The compound is soluble in water, which increases its bioavailability and makes it suitable for intravenous administration. Its stability under various conditions allows it to be effectively formulated into a drug product.
The unique structure of pemetrexed acid includes a sulfonamide group and multiple functional groups that enhance its ability to inhibit key enzymes of folate metabolism, such as thymidylate synthase, dihydrofolate reductase, and glycinamide nucleotide formyltransferase. This multi-target approach is critical to maximizing its therapeutic effect and minimizing drug resistance.
Pemetrexed acid is mainly used to treat malignant pleural mesothelioma and non-small cell lung cancer (NSCLC). It is usually used in combination with cisplatin to enhance its efficacy and improve patient prognosis. Clinical studies have shown that pemetrexed can significantly prolong the progression-free survival and overall survival of patients with these malignant tumors.
In addition to its primary use, pemetrexed acid is also being studied for the treatment of other solid tumors, including breast cancer and colorectal cancer. Its ability to inhibit multiple pathways of tumor growth has made it a drug of interest in various therapeutic areas.
As an enterprise integrating production, R&D and trading, our company is committed to providing customers with high-quality pemetrexed acid. We adhere to strict quality control measures throughout the production process to ensure that our products meet international standards. Our state-of-the-art facilities are equipped with advanced technology, allowing us to produce pemetrexed acid with high purity and consistent quality.
Our dedicated R&D team is constantly exploring new applications and synthetic methods for pemetrexed acid, ensuring that we are always at the forefront of innovation in the pharmaceutical industry. With customer satisfaction as our top priority, we provide our customers with comprehensive technical support and logistical assistance to help them navigate the complexities of drug development.
In conclusion, pemetrexed acid is an important therapeutic agent for the treatment of malignant pleural mesothelioma and non-small cell lung cancer, offering numerous benefits to patients facing these challenges. With its favorable physical and chemical properties, it serves as an effective solution to inhibit tumor growth and progression. Our company's commitment to quality, research, and customer support makes us a reliable partner for businesses seeking high-quality pemetrexed acid.
Whether you are involved in drug development or research, our products can help you achieve your goals in the evolving pharmaceutical landscape. To learn more about our pemetrexed acid and how it can benefit your project, contact us today!