Lefamulin Acetate CAS No. 1350636-82-6 (DMF) Antibacterial API
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introduce
Lefamulin Acetate is the first systemic pleuromutilin antibiotic raw material for human use. It blocks bacterial protein synthesis via unique 50S ribosome binding, indicated for adult community-acquired bacterial pneumonia (CABP) oral and injectable medicines.
Our strict quality control ensures consistent batch performance for pharmaceutical production needs.
Our strict quality control ensures consistent batch performance for pharmaceutical production needs.
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Physical and chemical properties
Lefamulin Acetate possesses key physical and chemical characteristics as follows:
- Hygroscopicity: Low moisture absorption under sealed storage
- Solubility: Freely soluble in DMSO; insoluble in neutral aqueous solution and aliphatic solvents
- Stability: Chemically stable under recommended storage; incompatible with strong oxidizing substances
- Storage Condition: Short-term storage at 2–4 °C sealed dry environment; long-term stable storage at -20 °C, avoid light and moisture
- Hygroscopicity: Low moisture absorption under sealed storage
- Solubility: Freely soluble in DMSO; insoluble in neutral aqueous solution and aliphatic solvents
- Stability: Chemically stable under recommended storage; incompatible with strong oxidizing substances
- Storage Condition: Short-term storage at 2–4 °C sealed dry environment; long-term stable storage at -20 °C, avoid light and moisture
Unique Antibacterial Mechanism
Dual-site induced-fit binding to A & P pockets of bacterial 50S ribosome peptidyl transferase center, blocks peptide chain elongation, no cross-resistance with quinolones, macrolides and beta-lactams.
Dual-site induced-fit binding to A & P pockets of bacterial 50S ribosome peptidyl transferase center, blocks peptide chain elongation, no cross-resistance with quinolones, macrolides and beta-lactams.
Broad Respiratory Pathogen Coverage
Potent bactericidal activity against Gram-positive bacteria, atypical pathogens and susceptible Gram-negative strains including macrolide-resistant isolates.
Excellent clinical application
High drug concentration in alveolar lining fluid, far exceeding plasma levels for targeted pneumonia treatment. Suitable raw material for both oral tablet and intravenous injection preparations, supports IV-to-oral switch clinical regimens.
Low Resistance Development Risk
Distinct ribosome binding mode greatly reduces mutation rate of target bacteria compared with mainstream antibiotics.
Community-Acquired Bacterial Pneumonia Therapy
Serves as the primary active pharmaceutical ingredient for oral tablets and intravenous injections. It targets mild-to-moderate community-acquired bacterial pneumonia in adult patients, with proven efficacy against these pathogenic strains:
Streptococcus pneumoniae, Haemophilus influenzae, Mycoplasma pneumoniae, Legionella pneumophila, Chlamydophila pneumoniae, and methicillin-sensitive Staphylococcus aureus.
Serves as the primary active pharmaceutical ingredient for oral tablets and intravenous injections. It targets mild-to-moderate community-acquired bacterial pneumonia in adult patients, with proven efficacy against these pathogenic strains:
Streptococcus pneumoniae, Haemophilus influenzae, Mycoplasma pneumoniae, Legionella pneumophila, Chlamydophila pneumoniae, and methicillin-sensitive Staphylococcus aureus.
Research Reference Standard
Acts as high-purity reference material for lab-based research projects, covering pleuromutilin pharmacology, bacterial resistance analysis, and respiratory infectious disease mechanism studies.
Lefamulin Acetate is a novel pleuromutilin API for human respiratory bacterial infections, featuring unique antibacterial activity and dual-formula suitability for pneumonia treatment.
Contact our team today for sample requests, technical specifications and bulk order inquiries—we’re committed to providing efficient and customized pharmaceutical raw material solutions for you.
Contact our team today for sample requests, technical specifications and bulk order inquiries—we’re committed to providing efficient and customized pharmaceutical raw material solutions for you.