Gatifloxacin CAS No. 112811-59-3 (DMF) Antibacterial API
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introduce
Gatifloxacin is a broad-spectrum fourth-generation fluoroquinolone API. It inhibits bacterial DNA gyrase and topoisomerase IV, active against Gram-positive, Gram-negative and atypical pathogens for systemic and ophthalmic infection formulations.
Our strict quality control ensures consistent batch performance for pharmaceutical production needs.
Our strict quality control ensures consistent batch performance for pharmaceutical production needs.
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Physical and chemical properties
Gatifloxacin possesses key physical and chemical characteristics as follows:
- Density: 1.386±0.06 g/cm³
- Melting Point: 162 °C
- Boiling Point: 607.8±55.0 °C
- Stability: Stable under recommended storage
- Storage Condition: Sealed dry environment at 2–8 °C, protected from strong light
- Solubility: Slightly soluble in heated methanol and chloroform; practically insoluble in pure water; soluble in dilute acid and alkaline aqueous solutions
- Density: 1.386±0.06 g/cm³
- Melting Point: 162 °C
- Boiling Point: 607.8±55.0 °C
- Stability: Stable under recommended storage
- Storage Condition: Sealed dry environment at 2–8 °C, protected from strong light
- Solubility: Slightly soluble in heated methanol and chloroform; practically insoluble in pure water; soluble in dilute acid and alkaline aqueous solutions
Balanced Broad-Spectrum Activity
Superior potency against Gram-positive strains (Streptococcus, Staphylococcus) compared to 3rd-gen quinolones, retains strong activity against common Gram-negative bacteria and atypical pathogens (Mycoplasma, Chlamydia, Legionella).
Superior potency against Gram-positive strains (Streptococcus, Staphylococcus) compared to 3rd-gen quinolones, retains strong activity against common Gram-negative bacteria and atypical pathogens (Mycoplasma, Chlamydia, Legionella).
Dual Enzyme Inhibition Mechanism
Targets both DNA gyrase and topoisomerase IV simultaneously, lowers bacterial resistance mutation probability.
Low Phototoxicity Profile
Less light-induced irritation risk than earlier quinolone analogues, suitable for oral tablets, injections and sterile ophthalmic administration.
High Tissue Penetration
Rapid tissue distribution; stable concentration maintained in ocular mucosal tissues after topical delivery.
Reliable Research Reference Value
High-purity grade available as HPLC standard for antibiotic residue detection and pharmacology research.
Bacterial Infection Therapy
Treat mild-to-moderate sensitive bacterial infections including acute sinusitis, chronic bronchitis exacerbation, community-acquired pneumonia, uncomplicated/complicated urinary tract infections, pyelonephritis and gonococcal genital infections.
Treat mild-to-moderate sensitive bacterial infections including acute sinusitis, chronic bronchitis exacerbation, community-acquired pneumonia, uncomplicated/complicated urinary tract infections, pyelonephritis and gonococcal genital infections.
Ophthalmic Drugs
Core raw material for antibacterial eye drops used to treat bacterial conjunctivitis caused by Staphylococcus, Streptococcus, Haemophilus and Moraxella species.
Laboratory Research & Testing Standard
Certified reference substance for microbial susceptibility tests, fluoroquinolone pharmacodynamic studies, and pharmaceutical impurity HPLC detection.
Gatifloxacin is a mature fourth-generation methoxyfluoroquinolone API with outstanding anti-Gram-positive and atypical pathogen activity. Limited to ophthalmic topical preparations and laboratory reference standards worldwide due to systemic glycemic toxicity risks, it remains a mainstream raw material for clinical bacterial conjunctivitis treatment and pharmaceutical analytical research.
Contact our team today for sample requests, technical specifications and bulk order inquiries—we’re committed to providing efficient and customized pharmaceutical raw material solutions for you.
Contact our team today for sample requests, technical specifications and bulk order inquiries—we’re committed to providing efficient and customized pharmaceutical raw material solutions for you.