Doxycycline Hyclate CAS No. 24390-14-5 (DMF) Antibacterial API
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introduce
Doxycycline Hyclate is a second-generation tetracycline API with broad-spectrum bacteriostatic activity against Gram-positive, Gram-negative bacteria, rickettsiae and mycoplasma. It also shows anti-inflammatory MMP inhibitory effects for clinical and veterinary formulations.
Our strict quality control ensures consistent batch performance for veterinary production needs.
Our strict quality control ensures consistent batch performance for veterinary production needs.
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Physical and chemical properties
Doxycycline Hyclat possesses key physical and chemical characteristics as follows:
- Boiling Point: 685.2 °C
- Flash Point: 368.2 °C
- Hygroscopicity: Slightly hygroscopic
- Storage Requirement: 2–8 °C, sealed dry container away from light
- Solubility: Freely soluble in water and methanol; sparingly soluble in ethanol; insoluble in chloroform and diethyl ether
- Boiling Point: 685.2 °C
- Flash Point: 368.2 °C
- Hygroscopicity: Slightly hygroscopic
- Storage Requirement: 2–8 °C, sealed dry container away from light
- Solubility: Freely soluble in water and methanol; sparingly soluble in ethanol; insoluble in chloroform and diethyl ether
Superior Antibacterial Potency
2–10 times higher activity than oxytetracycline against most susceptible strains, effective against partial tetracycline-resistant bacteria.
2–10 times higher activity than oxytetracycline against most susceptible strains, effective against partial tetracycline-resistant bacteria.
Excellent Oral Bioavailability
Absorption rate over 90%; food has minimal impact on uptake; long half-life (16–22 h) supports once/twice daily dosing.
Strong Tissue Penetration
Easily enters intracellular compartments, reaching high concentrations in respiratory, urinary and soft tissues.
Mild Renal Burden
Mainly excreted via bile; dosage adjustment rarely required for mild-moderate renal impairment patients.
Dual Pharmacological Functions
Besides antibacterial effect, it inhibits matrix metalloproteinases (MMPs) to relieve inflammatory lesions.
Wide Formulation Compatibility
Good water solubility suitable for tablets, capsules, oral liquids and veterinary premixes.
Human Pharmaceutical Field
Core raw material for drugs treating respiratory tract infections, chlamydia, mycoplasma pneumonia, rickettsiosis, Lyme disease and malaria prophylaxis. Also used for chronic inflammatory adjuvant therapy.
Core raw material for drugs treating respiratory tract infections, chlamydia, mycoplasma pneumonia, rickettsiosis, Lyme disease and malaria prophylaxis. Also used for chronic inflammatory adjuvant therapy.
Veterinary Pharmaceutical Field
Applied in livestock and aquaculture premixes to control bacterial diseases caused by vibrio, clostridium and mycoplasma in pigs, poultry and aquatic animals.
Biochemical Research Reagent
Used for Tet-On/Tet-Off gene expression induction and MMP inhibition mechanism research in cell & animal experiments.
Doxycycline Hyclate features convenient administration, low renal toxicity and wide application coverage in human medicine, veterinary products and laboratory research, maintaining stable long-term market demand.
Contact our team today for sample requests, technical specifications and bulk order inquiries—we’re committed to providing efficient and customized pharmaceutical material solutions for you.
Contact our team today for sample requests, technical specifications and bulk order inquiries—we’re committed to providing efficient and customized pharmaceutical material solutions for you.