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    0102030405
    1235865-75-4 ABT199 INT 2 结构式.png
    1235865-75-4 ABT199 INT 2 外观.png
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    CAS NO 1235865-75-4 ABT199 INT 2 Pharmaceutical Intermediates

    Product name

    ABT199 INT 2

    CAS No.

    1235865-75-4

    EINECS  

    /

    Formula

    C15H11FN2O3

    Molecular Weight

    286.26

    Appearance

    White to off-white powder

    Purity

    ≥98%

    Type

    Pharmaceutical Intermediates

     High Purity: Our ABT199 INT 2 is manufactured to the highest purity standards, ensuring reliable performance in pharmaceutical applications.

     Targeted Action: The compound is a key intermediate in the synthesis of Venetoclax, a potent BCL-2 inhibitor for cancer treatment.

     Integrated Production and Trading: As a production and trading integrated factory, we provide competitive prices and a stable supply of high-quality chemicals.

    Expertise and Experience: With many years of experience in chemical manufacturing, we guarantee that our products meet the highest industry standards.

    Custom Solutions: We offer custom solutions to meet specific customer requirements, including custom synthesis and packaging options.

      Contact us
      product details

      Product details

      138982-67-9 ZIPRASIDONE HYDROCHLORIDE 外包装3
      02

      Product detail

      ABT199 INT 2 is a unique chemical compound that is an important intermediate in the synthesis of the selective B-cell lymphoma 2 (BCL-2) inhibitor Venetoclax. Venetoclax is primarily used to treat hematological malignancies, including chronic lymphocytic leukemia (CLL) and acute myeloid leukemia (AML). By inhibiting the BCL-2 protein, ABT199 INT 2 plays a key role in promoting apoptosis (programmed cell death) in cancer cells, thereby reducing tumor burden and improving patient outcomes.

      188416-29-7 外包装 (2)
      02

      product detail

      CAS No.

      40856-44-8

      EINECS 

      609-874-3

      Formula

      C9H11NO2

      Molecular Weight

      165.19

      Appearance

      White to Off-White solid

      Purity

      ≥98%

      Type

      Pharmaceutical Intermediates

      Advantages 

      1. Enhanced Therapeutic Potential: As a key intermediate in the synthesis of Venetoclax, ABT199 INT 2 contributes to the development of new therapeutic agents for the treatment of blood cancers, bringing significant benefits to patients.
      2. Customizable Synthesis: Our integrated factory capabilities enable us to offer customized synthesis options, allowing customers to obtain specific derivatives or formulations tailored to their R&D needs.
      3. Regulatory Compliance: We adhere to strict regulatory standards to ensure our products meet international quality and safety regulations and are suitable for pharmaceutical applications.
      4. Reliable supply chain: As a production and trading integrated factory, we maintain a strong supply chain to ensure timely delivery and continuous supply of products.
      5. Expert Support: Our team of experienced chemists and industry experts can provide technical support and guidance to help customers solve complex drug development problems.

      Pharmaceutical Applications

      ABT199 INT 2 is primarily used in the pharmaceutical industry as an intermediate in the synthesis of Venetoclax. Its unique mechanism of action enables it to effectively control symptoms associated with hematological malignancies, including:
       - Chronic Lymphocytic Leukemia (CLL): ABT199 INT 2 is critical for the production of Venetoclax, which is indicated for the treatment of CLL, particularly in patients with 17p deletion or who have received prior treatment.
       - Acute Myeloid Leukemia (AML): Venetoclax, synthesized from ABT199 INT 2, is being studied in combination with other drugs for the treatment of AML.
       - Combination Therapies: ABT199 INT 2 is critical to developing combination therapies to enhance treatment efficacy and improve patient outcomes.

      Physical and chemical properties

      - Molecular formula: C28H31ClN6O4S
       - Molecular weight: 868.10 g/mol
       - Appearance: White to off-white crystalline powder
       - Solubility: Soluble in dimethyl sulfoxide (DMSO) and methanol; slightly soluble in water.
       - Melting point: approx. 150-155°C
       - Stability: ABT199 INT 2 is stable under normal storage conditions, keep in a cool and dry place, avoid direct sunlight, and the recommended shelf life is two years.
       The physical and chemical properties of ABT199 INT 2 make it an ideal candidate for various applications in drug formulation and development. Its solubility properties allow for easy incorporation into different dosage forms, thereby improving bioavailability and therapeutic efficacy. The stability of the compound ensures that it maintains its effectiveness throughout its shelf life, making it a reliable choice for pharmaceutical manufacturers.

      In summary

        In summary, ABT199 INT 2 is a high-quality compound with great potential in the pharmaceutical industry. With our commitment to quality, expertise and customer satisfaction, we are a trusted partner for all your chemistry needs. Contact us today to learn more about our products and how we can support your drug development projects. Our commitment to innovation and excellence ensures that you receive the best possible products tailored to your specific requirements.