Molecular Formula: C₂₀H₂₉ClN₂O₅S
Synonyms: Benzenesulfonamide,5-[(2R)-2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxy-,monohydrochloride (9CI); Benzenesulfonamide,5-[2-[[2-(2-ethoxyphenoxy)ethyl]amino]propyl]-2-methoxy-, monohydrochloride,(R)-; (-)-YM 12617; (R)-(-)-YM 12617; Flomax; Harnal; LY 253351; Omic; Omnic; YM 12617-1; YM 617; Yutanal; Tamsulosin HCl;
Appearance: White to Off-White Solid
Molecular Weight: 444.97
Boiling Point: 595.5 °C at 760 mmHg
Melting Point: 228-230℃
Flash Point: 313.9 °C
Solubility: In water, 215.9 mg/L at 25 deg C (est)
Biological Activity: Selective α 1A -adrenoceptor antagonist (pK i values are 9.97, 9.64 and 8.86 for α 1A , α 1B and α 1D subtypes respectively). Decreases resting maximal urethral pressure with negligable effect on mean arterial blood pressure in vivo .
Usage: Specific a1-adrenoceptor antagonist. Used in the treatment of benign prostatic hypertrophy