Molecular Formula: C₅₁H₇₉NO₁₃
Synonyms: Stereoisomer of 9,10,12,13,14,21,22,23,24,25,26,27,32,33,34, 34a-hexadecahydro-9,27-dihydroxy-3-[2-(4-hydroxy-3- methoxycyclohexyl)-1-methylethyl]-10,21-dimethoxy-6,8,12,14, 20, 26-hexamethyl-23,27-epoxy-3H-pyrido[2,1-c][1, 4]oxaazacyclohentriacontine-1,5,11,28,29(4H,6H,31H)-pentone; RAP; Sirolimus [USAN:BAN:INN]; 23,27-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine-1,5,11,28,29; AY 22989; Rapamycin (TN); RPM;
Appearance: yellow solid
Molecular Weight: 914.17186
Density: 1.182 g/cm3
Boiling Point: 973.017 oC at 760 mmHg
Melting Point: 183-185 oC
Flash Point: 542.261 oC
Storage Temperature: -20°C
Refractive index: 1.55
Solubility: Soluble in DMSO and Methanol
Biological Activity: Antifungal and immunosuppressant. Specific inhibitor of mTOR (mammalian target of Rapamycin). Complexes with FKBP-12 and binds mTOR inhibiting its activity. Inhibits interleukin-2-induced phosphorylation and activation of p70 S6 kinase.
Stability: Stable if stored as directed.
Usage: Used as an immunosuppressant